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Nature genetics · 2025

Genome-wide association study of long COVID.

СтатьяНазвание и аннотация: Перевод в очереди
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Lammi Vilma, Nakanishi Tomoko, Jones Samuel E, Andrews Shea J, Karjalainen Juha, Cortés Beatriz, O'Brien Heath E, Ochoa-Guzman Ana, Fulton-Howard Brian E, Broberg Martin, Haapaniemi Hele H, Kanai Masahiro, Pirinen Matti, Schmidt Axel, Mitchell Ruth E, Mousas Abdou, Mangino Massimo, Huerta-Chagoya Alicia, Sinnott-Armstrong Nasa, Cirulli Elizabeth T, Vaudel Marc, Kwong Alex S F, Maiti Amit K, Marttila Minttu M, Posner Daniel C, Rodriguez Alexis A, Batini Chiara, Minnai Francesca, Dearman Anna R, Warmerdam C A Robert, Sequeros Celia B, Winkler Thomas W, Jordan Daniel M, Rešcenko Raimonds, Miano Lorenzo, Lane Jacqueline M, Chung Ryan K, Guillen-Guio Beatriz, Leavy Olivia C, Carvajal-Silva Laura, Aguilar-Valdés Kevin, Frangione Erika, Guare Lindsay, Vergasova Ekaterina, Marouli Eirini, Striano Pasquale, Zainulabid Ummu Afeera, Kumar Ashutosh, Ahmad Hajar Fauzan, Edahiro Ryuya, Azekawa Shuhei, Long COVID Host Genetics Initiative, FinnGen, VA Million Veteran Program, MexGen-COVID Initiative, DBDS Genomic Consortium, GEN-COVID Multicenter Study, PHOSP-COVID Collaborative Group, GENCOV Study, Estonian Biobank Research Team, Luoh Shiuh-Wen, Erikstrup Christian, Pedersen Ole B V, Lerner-Ellis Jordan, Colombo Alicia, Grzymski Joseph J, Ishii Makoto, Okada Yukinori, Beckmann Noam D, Kumari Meena, Wagner Ralf, Heid Iris M, John Catherine, Short Patrick J, Magnus Per, Ansone Laura, Valenti Luca V C, Lee Sulggi A, Wain Louise V, Verdugo Ricardo A, Banasik Karina, Geller Frank, Franke Lude H, Rakitko Alexander, Duncan Emma L, Renieri Alessandra, Tsilidis Konstantinos K, de Cid Rafael, Niavarani Ahmadreza, Abner Erik, Tusié-Luna Teresa, Verma Shefali S, Smith George Davey, Timpson Nicholas J, Madduri Ravi K, Cho Kelly, Daly Mark J, Ganna Andrea, Schulte Eva C, Richards J Brent, Ludwig Kerstin U, Marks-Hultström Michael, Zeberg Hugo, Ollila Hanna M

Аннотация

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4's role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты