Severe hypotension associated with angiotensin-converting enzyme inhibition in anaesthesia.

Three cases of severe hypotension associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) and intravenous administration of the synthetic colloid Gelofusin (Braun Medical Ltd) are presented. A possible mechanism of interaction between ACEIs and Gelofusin is discussed. All three patients were treated successfully.