Distribution and clearance from the body of an oxypolygelatin plasma substitute determined by radioactive tracer study in chimpanzees.

The organ distribution of a colloidal plasma substitute on the basis of oxypolygelatin (Gelifundol S) has been determined in chimpanzees with radioactively tagged material. The radioactivity was distributed uniformly in the whole body and after 24 h it was nearly completely excreted. As liver, spleen, heart, lungs and kidneys were not depicted radiographically in contrast to the body background, it can be concluded that ther e is no preference for the colloid to be stored in any of these organs. Only in the bladder a transiently higher radioactivity could be measured. The urine was collected fo 7 d and contained 91.5% of the colloid originally infused.