Neuropsychopharmacology reports · 2026
Effect of the rs7858836 Single-Nucleotide Polymorphisms of the ASTN2 Gene on Pain-Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery.
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Inoue Rie, Nishizawa Daisuke, Okahara Shoko, Hara Atsuko, Okada Hisako, Hasegawa Junko, Ebata Yuko, Nakayama Kyoko, Hayashida Masakazu, Ikeda Kazutaka
Аннотация
BACKGROUND: In our previous study, the minor T allele of the rs7858836 C/T single-nucleotide polymorphism (SNP) in the ASTN2 gene, which encodes astrotactin 2, was associated with reduced fentanyl requirements after laparoscopic-assisted colectomy and after mandibular osteotomy. In this study, we investigated the effects of this SNP on pain-related phenotypes in patients who underwent laparoscopic gynecologic surgery (LGS).
METHODS: We studied 333 Japanese women, 21-69 years, who underwent LGS at Juntendo University Hospital between 2017 and 2019. We evaluated associations between SNP genotypes and postoperative pain-related phenotypes, including fentanyl requirements, rescue analgesic requirements, and the average pain scores on an 11-point Numeric Rating Scale (NRS) during the 24-h postoperative period. Patients with the TT or CT genotype were compared with those with the CC genotype using the Mann-Whitney test or χ2 test. Values of p < 0.05 were considered statistically significant.
RESULTS: The minor T allele frequency was 34.1%. Patients with the CT or TT genotype reported significantly lower average NRS pain scores (median, 1.6 vs. 2.0; p = 0.031) and required fewer rescue analgesics (5.5% vs. 15.0%; p = 0.003) compared to those with the CC genotype. Postoperative fentanyl requirements did not differ between the two groups (p = 0.940).
CONCLUSION: The minor T allele of the rs7858836 SNP was significantly associated with lower postoperative pain intensity, albeit only slightly, and decreased the need for rescue analgesics under comparable fentanyl dosing conditions, potentially reflecting lower pain sensitivity. However, the magnitude of the effect was less than our previous findings.
METHODS: We studied 333 Japanese women, 21-69 years, who underwent LGS at Juntendo University Hospital between 2017 and 2019. We evaluated associations between SNP genotypes and postoperative pain-related phenotypes, including fentanyl requirements, rescue analgesic requirements, and the average pain scores on an 11-point Numeric Rating Scale (NRS) during the 24-h postoperative period. Patients with the TT or CT genotype were compared with those with the CC genotype using the Mann-Whitney test or χ2 test. Values of p < 0.05 were considered statistically significant.
RESULTS: The minor T allele frequency was 34.1%. Patients with the CT or TT genotype reported significantly lower average NRS pain scores (median, 1.6 vs. 2.0; p = 0.031) and required fewer rescue analgesics (5.5% vs. 15.0%; p = 0.003) compared to those with the CC genotype. Postoperative fentanyl requirements did not differ between the two groups (p = 0.940).
CONCLUSION: The minor T allele of the rs7858836 SNP was significantly associated with lower postoperative pain intensity, albeit only slightly, and decreased the need for rescue analgesics under comparable fentanyl dosing conditions, potentially reflecting lower pain sensitivity. However, the magnitude of the effect was less than our previous findings.