American journal of obstetrics & gynecology MFM · 2025
Establishing a prospective cohort to examine the impact of medication for opioid use disorder in pregnancy.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Townsel Courtney, Biroon Fatemeh, Broni Eric K, Turner Makeda D, Govindan Vedavalli, Sabet Sarah, Tarui Ai A, Willimas Samantha A S, Goodrich Jackie M, Dolinoy Dana C, Kelly Jeannie C
Аннотация
OBJECTIVE: To describe the design and initial findings of a prospective cohort study examining the impact of opioid treatment during pregnancy on maternal and infant outcomes.
STUDY DESIGN: A multi-site prospective cohort study of 127 pregnancies (including 3 sets of twins), comprising 86 individuals with medication for opioid use disorder exposure and 41 matched controls. Data collection included structured clinical interviews, medical record abstraction, and biospecimen sampling from maternal and neonatal sources.
RESULTS: The cohort is predominantly non-Hispanic White and multiparous. Among opioid-exposed participants, mood disorders, nicotine use, and hepatitis C were common. Over 80% of opioid-exposed infants developed neonatal withdrawal, with nearly half experiencing severe symptoms.
CONCLUSIONS: High rates of co-occurring conditions were observed among pregnant individuals receiving medication for opioid use disorder. Most opioid-exposed neonates developed neonatal withdrawal. This cohort provides a rich clinical resource for investigating the effects of prenatal opioid exposure on maternal and infant health.
STUDY DESIGN: A multi-site prospective cohort study of 127 pregnancies (including 3 sets of twins), comprising 86 individuals with medication for opioid use disorder exposure and 41 matched controls. Data collection included structured clinical interviews, medical record abstraction, and biospecimen sampling from maternal and neonatal sources.
RESULTS: The cohort is predominantly non-Hispanic White and multiparous. Among opioid-exposed participants, mood disorders, nicotine use, and hepatitis C were common. Over 80% of opioid-exposed infants developed neonatal withdrawal, with nearly half experiencing severe symptoms.
CONCLUSIONS: High rates of co-occurring conditions were observed among pregnant individuals receiving medication for opioid use disorder. Most opioid-exposed neonates developed neonatal withdrawal. This cohort provides a rich clinical resource for investigating the effects of prenatal opioid exposure on maternal and infant health.