Case reports in ophthalmology · 2025
Recurrent Subretinal Hemorrhage in a Patient Taking a Turmeric Supplement: Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yu Yibing, Zhao Qingsong, Zang Yu, Liu Zhiqiang, Du Weijia
Аннотация
PURPOSE: To compare analgesic outcomes between single- and multi-orifice epidural catheters at a 360-mL/h delivery rate during programmed intermittent epidural bolus.
PATIENTS AND METHODS: In this prospective randomized double-blinded controlled trial, 102 healthy nulliparous parturients requesting labor analgesia at the Shanghai First Maternity and Infant Hospital were enrolled from July to September 2023. Participants were given either single- or multi-orifice catheters for epidural analgesia (0.1% ropivacaine with 0.3 µg/mL of sufentanil; 10 mL every 45 min at 360 mL/h). The primary outcome was ropivacaine consumption per hour, calculated as the total amount of ropivacaine administered divided by the duration of labor analgesia (mg/h).
RESULTS: Median ropivacaine consumption per hour was not significantly different: 12.6 mg/h [11.6-13.2 mg/h] for single-orifice vs 12.8 mg/h [12.3-13.3 mg/h] for multi-orifice catheters (difference 29%; 95% confidence interval [CI], -10.2 to 68.2%; P=0.241). No significant differences were found in patient-controlled epidural analgesia boluses requested and delivered, time to first bolus request, or the number of clinician-administered boluses. However, adequate analgesia at 20 min was higher with single-orifice catheters (84.0% vs 63.5%, difference 22.5%; 95% CI: 9.2% to 35.1%, P=0.019). Median times to adequate analgesia were 8 min [4-16] vs 15 min [9.5-22.5] for single- and multi-orifice catheters (P=0.002). Pain scores differed only at 6 and 18 min. There were no differences in the incidence of motor or unilateral block, side effects, maternal satisfaction, or catheter-related complications between the two groups.
CONCLUSION: Single-orifice catheters did not enhance analgesia quality during labor maintenance under a 360-mL/h programmed intermittent epidural bolus delivery rate but were linked to more rapid analgesic onset than multi-orifice catheters.
PATIENTS AND METHODS: In this prospective randomized double-blinded controlled trial, 102 healthy nulliparous parturients requesting labor analgesia at the Shanghai First Maternity and Infant Hospital were enrolled from July to September 2023. Participants were given either single- or multi-orifice catheters for epidural analgesia (0.1% ropivacaine with 0.3 µg/mL of sufentanil; 10 mL every 45 min at 360 mL/h). The primary outcome was ropivacaine consumption per hour, calculated as the total amount of ropivacaine administered divided by the duration of labor analgesia (mg/h).
RESULTS: Median ropivacaine consumption per hour was not significantly different: 12.6 mg/h [11.6-13.2 mg/h] for single-orifice vs 12.8 mg/h [12.3-13.3 mg/h] for multi-orifice catheters (difference 29%; 95% confidence interval [CI], -10.2 to 68.2%; P=0.241). No significant differences were found in patient-controlled epidural analgesia boluses requested and delivered, time to first bolus request, or the number of clinician-administered boluses. However, adequate analgesia at 20 min was higher with single-orifice catheters (84.0% vs 63.5%, difference 22.5%; 95% CI: 9.2% to 35.1%, P=0.019). Median times to adequate analgesia were 8 min [4-16] vs 15 min [9.5-22.5] for single- and multi-orifice catheters (P=0.002). Pain scores differed only at 6 and 18 min. There were no differences in the incidence of motor or unilateral block, side effects, maternal satisfaction, or catheter-related complications between the two groups.
CONCLUSION: Single-orifice catheters did not enhance analgesia quality during labor maintenance under a 360-mL/h programmed intermittent epidural bolus delivery rate but were linked to more rapid analgesic onset than multi-orifice catheters.