Journal of addiction medicine · 2023
48-hour Induction of Transdermal Buprenorphine to Extended-release Buprenorphine.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Azar Pouya, Wong James S H, Mathew Nickie, Ignaszewski Martha J, Partovi Nilufar, Krausz Reinhard M, Ajidahun Adedayo, Thotakura Sahithi, Harris Marianne, Barrios Rolando, Montaner Julio S G, Maharaj Anil R
Аннотация
Buprenorphine extended-release (BUP-XR) provides sustained delivery of buprenorphine to control withdrawal and craving symptoms in the form of a monthly injectable and has been shown to improve health outcomes in patients with opioid use disorder. It is recommended that patients are stabilized with a transmucosal buprenorphine product, for at least 7 days per the product monograph; however, clinically, this timeline may be expedited. We report a case of a hospitalized patient with unregulated fentanyl use who underwent a successful transdermal buprenorphine induction for 48 hours to initiate BUP-XR with minimal levels of withdrawal and without precipitating opioid withdrawal. The approach described could provide a practical, patient-centered, accelerated induction strategy that, once independently validated, could considerably facilitate the use of BUP-XR.