Drug Overdose Mortality of Residents and Visitors to Cities.

Background: The ongoing drug epidemic in the United States has shown that there are geographic differences in overdose fatalities. This article introduces a new way to study spatial differences in drug-related mortality, by distinguishing the fatalities of residents and visitors to a region. Methods: Using records of United States deaths from 2001 to 2020, this study examined fatal overdoses among residents and visitors to U.S. metropolitan areas. Results: The findings revealed that the drug fatality levels of residents and visitors differed from one another in many cities. These differences were most pronounced in larger metro areas, where the drug mortality of visitors was disproportionately high. Conclusions: Discussion focuses on implications and possible explanations for these findings, as well as their potential connection to classical conditioning of drug tolerance. More generally, comparing the fatalities of residents and visitors may provide a way to tease apart the roles of person-specific and location-specific contributors to overdose risk.