Diabetes research and clinical practice · 2025
Impact of lifestyle changes on prediabetes remission: Results from the Pakistan diabetes prevention trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ahmed Asma, Ahmed Salaar, Shah Wasiat Hasan, Iqbal Romaina, Akhter Jaweed, Jabbar Abdul, Azam Iqbal, Awan Safia, Tuomilehto Jaakko
Аннотация
BACKGROUND: This study evaluated the effectiveness of a culturally adapted lifestyle intervention in prediabetes remission to normoglycemia and reducing diabetes progression.
METHODS: In two sub-towns of Karachi, 3945 adults were screened with the Indian Diabetes Risk Score; 2165 high-risk participants (aged 30-64 years) were randomized to lifestyle intervention or standard care. The intervention included nine structured sessions on diet, activity, and weight management, plus SMS reminders, cooking demonstrations, and counseling. Participants were followed for two years.
RESULTS: Mean age was 44 years, and 74 % were women; 43 % had prediabetes at baseline. Reversal to normoglycemia occurred in 61 % and 62 % of the intervention group at one and two years versus 39 % and 37 % in standard care (AOR = 2.46, 95 % CI: 1.84-3.29, p < 0.0001). Lower prediabetes remission was observed among overweight (AOR = 0.65), pre-obese (AOR = 0.59), and obese participants (AOR = 0.74). Remission was lower in areas with parks (AOR = 0.77, p = 0.0001). Metabolic syndrome participants in the intervention had higher remission rates (AOR = 4.13). Those with impaired fasting glucose showed markedly greater remission odds (AOR = 8.21).
CONCLUSION: Culturally tailored lifestyle interventions can significantly induce prediabetes remission, highlighting scalable, low-cost prevention strategies for Pakistan and other LMICs.
METHODS: In two sub-towns of Karachi, 3945 adults were screened with the Indian Diabetes Risk Score; 2165 high-risk participants (aged 30-64 years) were randomized to lifestyle intervention or standard care. The intervention included nine structured sessions on diet, activity, and weight management, plus SMS reminders, cooking demonstrations, and counseling. Participants were followed for two years.
RESULTS: Mean age was 44 years, and 74 % were women; 43 % had prediabetes at baseline. Reversal to normoglycemia occurred in 61 % and 62 % of the intervention group at one and two years versus 39 % and 37 % in standard care (AOR = 2.46, 95 % CI: 1.84-3.29, p < 0.0001). Lower prediabetes remission was observed among overweight (AOR = 0.65), pre-obese (AOR = 0.59), and obese participants (AOR = 0.74). Remission was lower in areas with parks (AOR = 0.77, p = 0.0001). Metabolic syndrome participants in the intervention had higher remission rates (AOR = 4.13). Those with impaired fasting glucose showed markedly greater remission odds (AOR = 8.21).
CONCLUSION: Culturally tailored lifestyle interventions can significantly induce prediabetes remission, highlighting scalable, low-cost prevention strategies for Pakistan and other LMICs.