Future oncology (London, England) · 2022
Increased quality of life in patients with breakthrough cancer pain after individualized therapy: the CAVIDIOM study.
Многоцентровое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Villarroel Paula González, Padró Josep Gumà, Marquina Gloria, Jáñez Noelia Martínez, González Emilio Esteban, Antón Antonio, Sánchez Miguel Berzosa, Cáceres Alberto Rodrigo, López-López Rafael, Cornejo Roberto Escala, García Pablo Borrega, Fabregat Raquel Marse, Fernández Beatriz Castelo, Bermudo Cristina López, Camps Carlos
Аннотация
Aim: To evaluate the quality of life (QoL) in patients with breakthrough cancer pain (BTcP) in Spanish medical oncology departments. Patients & methods: In a prospective, observational, multicenter study, we assessed QoL using the EQ-5D-5L instrument at baseline and after 15 and 30 days of individualized BTcP therapy, as well as BTcP characteristics and treatment. Results: Patients (n = 118) were mainly women, over 64 years old and with advanced cancer. QoL improved at 15 (p = 0.013) and 30 days (p = 0.011) versus baseline. Individualized BTcP therapy consisted mostly of rapid-onset opioids (transmucosal fentanyl at doses of 67-800 μg) according to the physician evaluation. BTcP improved, including statistically significant reductions in intensity, duration, number of episodes in the last 24 h and time to onset of BTcP relief. Conclusion: QoL increased after individualized pain therapy in patients with advanced cancer and BTcP in medical oncology departments.