AIDS research and human retroviruses · 2024
Virologic Nonsuppression and HIV Drug Resistance Among People Who Inject Drugs and Their Sexual and Injecting Partners in Kenya.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Chohan Bhavna H, Kingston Hanley, Tseng Ashley S, Sambai Betsy, Guthrie Brandon L, Wilkinson Eduan, Giandhari Jennifer, Mbogo Loice W, Monroe-Wise Aliza, Masyuko Sarah, Bosire Rose, Ludwig-Barron Natasha T, Sinkele William, Bukusi David, de Oliveria Tulio, Farquhar Carey, Herbeck Joshua T
Аннотация
We evaluated the prevalence and correlates of HIV viral nonsuppression and HIV drug resistance (HIV-DR) in a cohort of people who inject drugs living with HIV (PWID-LH) and their sexual and injecting partners living with HIV in Kenya. HIV-DR testing was performed on participants with viral nonsuppression. Of 859 PWID-LH and their partners, 623 (72.5%) were on antiretroviral therapy (ART) ≥4 months and 148/623 (23.8%) were not virally suppressed. Viral nonsuppression was more common among younger participants and those on ART for a shorter duration. Among 122/148 (82.4%) successfully sequenced samples, 55 (45.1%) had detectable major HIV-DR mutations, mainly to non-nucleoside and nucleotide reverse transcriptase inhibitors (NNRTI and NRTI). High levels of HIV-DR among those with viral nonsuppression suggests need for viral load monitoring, adherence counseling, and timely switching to alternate ART regimens in this key population.