Journal of the American Pharmacists Association : JAPhA · 2007
Pharmacoepidemiology of potential alcohol-prescription drug interactions among primary care patients with alcohol-use disorders.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Brown Richard L, Dimond Alan R, Hulisz Darrell, Saunders Laura A, Bobula James A
Аннотация
OBJECTIVE: To report on the proportion of individuals with alcohol-use disorders who take prescription medications that could interact with alcohol and on the proportion who recall advice to avoid alcohol with their medications.
DESIGN: Secondary analysis of a randomized controlled trial of telephone counseling.
SETTING: 18 primary care practices in south-central and southeastern Wisconsin.
PATIENTS: 897 adults with alcohol-use disorders as identified by systematic survey.
INTERVENTION: Telephone and mail survey.
MAIN OUTCOME MEASURES: Patient-reported prescription medication use, potential for alcohol-drug interactions according to DrugDex, and patient-reported receipt of advice not to take alcohol with their medications.
RESULTS: Of the 869 patients who provided usable information on prescription medication use, 348 (40.0%) were taking medications with alcohol interactions or proscriptions; the most frequently reported were bupropion, selective serotonin reuptake inhibitors, and various acetaminophen-containing compounds. Slightly more than 20% of patients were taking medications with moderate to severe alcohol interactions; over one-third of these 184 patients did not recall advice to avoid alcohol.
CONCLUSION: Practitioners who prescribe or dispense medications may need to enhance their efforts to advise patients about alcohol-drug interactions. Prescribing and dispensing medications that interact with alcohol present opportunities to administer alcohol screens and interventions.
DESIGN: Secondary analysis of a randomized controlled trial of telephone counseling.
SETTING: 18 primary care practices in south-central and southeastern Wisconsin.
PATIENTS: 897 adults with alcohol-use disorders as identified by systematic survey.
INTERVENTION: Telephone and mail survey.
MAIN OUTCOME MEASURES: Patient-reported prescription medication use, potential for alcohol-drug interactions according to DrugDex, and patient-reported receipt of advice not to take alcohol with their medications.
RESULTS: Of the 869 patients who provided usable information on prescription medication use, 348 (40.0%) were taking medications with alcohol interactions or proscriptions; the most frequently reported were bupropion, selective serotonin reuptake inhibitors, and various acetaminophen-containing compounds. Slightly more than 20% of patients were taking medications with moderate to severe alcohol interactions; over one-third of these 184 patients did not recall advice to avoid alcohol.
CONCLUSION: Practitioners who prescribe or dispense medications may need to enhance their efforts to advise patients about alcohol-drug interactions. Prescribing and dispensing medications that interact with alcohol present opportunities to administer alcohol screens and interventions.