Addiction & health · 2026
Comparative Evaluation of the Effect of Pharmacotherapy, Low-Level Laser Therapy, and Behavioral Counseling on Tobacco Cessation: A Parallel Randomized Clinical Trial.
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Shukla Neha, Akram Zainab, Khairnar Mahesh Ravindra, Pg Naveen Kumar, Kumar Jadhav Sachin, Santhanam Savitha Priyadarsini
Аннотация
BACKGROUND: Nicotine lozenges help reduce nicotine gradually. They are a discreet NRT alternative. This study compared nicotine dependence, cotinine levels, quit rates, and physical effects before and after one month of NRT lozenges, laser therapy, and counselling.
METHODS: This randomised controlled trial tested nicotine lozenges, laser therapy, and counselling. This trial included 75 participants (25 per group) over one month. Seventy-five participants were divided into three groups of 25. The "Jus-CheckTM Rapid Nicotine Test" was used. Laser therapy targeted both ears weekly for four weeks, with counselling provided weekly. Primary outcomes included nicotine dependence, cotinine levels (saliva/urine), and quit rates; whereas, secondary outcomes included physical effects before and after intervention.
FINDINGS: The results showed a significant decrease in nicotine dependence and cotinine (P<0.001) in all groups. However, differences between groups and quit rates were not statistically significant.
CONCLUSION: Nicotine lozenges are as effective as laser therapy and counselling for quitting smokeless tobacco. This approach reduces dependence, lowers cotinine, increases quit rates, and improves physical effects.
METHODS: This randomised controlled trial tested nicotine lozenges, laser therapy, and counselling. This trial included 75 participants (25 per group) over one month. Seventy-five participants were divided into three groups of 25. The "Jus-CheckTM Rapid Nicotine Test" was used. Laser therapy targeted both ears weekly for four weeks, with counselling provided weekly. Primary outcomes included nicotine dependence, cotinine levels (saliva/urine), and quit rates; whereas, secondary outcomes included physical effects before and after intervention.
FINDINGS: The results showed a significant decrease in nicotine dependence and cotinine (P<0.001) in all groups. However, differences between groups and quit rates were not statistically significant.
CONCLUSION: Nicotine lozenges are as effective as laser therapy and counselling for quitting smokeless tobacco. This approach reduces dependence, lowers cotinine, increases quit rates, and improves physical effects.