Research square · 2026

Environmental determinants of Parkinson's disease and attributable burden in Latin America.

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Teixeira-Dos-Santos Daniel, Chaparro-Solano Henry Mauricio, Duarte-Zambrano Juan Felipe, Leal Thiago, Inca-Martinez Miguel, Waldo Emily, Noyce Alastair, Adamec Dario Sergio, Gatto Emilia Mabel, Santos-Lobato Bruno Lopes, Duarte Juliana Dos Santos, Cardoso Francisco Eduardo Costa, Letro Grace Helena, Arboleda Gonzalo, Orozco Jorge, Ospina Beatriz Muñoz, Medina-Cordero Paola, Chana-Cuevas Pedro, Pizarro-Correa Ximena, Salles Philippe, Aguillon David, Pineda David, Martínez Susana Lissette Peña, Ascencio Tatiana, Müller Maria Valentina, Merello Marcelo, Wainberg Florencia Nicole, Braga-Neto Pedro, Rangel Deborah, Tela Marcela Susana, Álvarez-Herrera Evelin, Rodríguez-Violante Mayela, Cervantes-Arriaga Amin, Martinez-Ramirez Daniel, Schuh Artur, Rieder Carlos, Cornejo-Olivas Mario, Armas Cintia, Rios-Pinto Julia, Medina-Colque Angel, Mejia-Rojas Koni, Viñuela Angel, Rosso Ana Lucia, Kauffman Marcelo, Tumas Vitor, Vilela Gabriel, Borges Vanderci, Avila Cesar, Olguín Patricio, Colombo Alicia, Nuñez Juan Cristobal, Jorquera Samuel, Fernandez-Toledo Elias, Lázaro-Figueroa Alejandra, Esquivias-Farías Juan Manuel, Estrada-Bellmann Ingrid, Reyes-Pérez Paula, Medina-Rivera Alejandra, Alcauter Sarael, Muñoz-Quezada María Teresa, Mata Ignacio

Аннотация

We investigated environmental determinants of Parkinson's disease (PD) and their attributable burden in a case-control study of 9,887 participants from nine Latin American countries. Logistic regression adjusted for age, sex, and country estimated associations, and population attributable fractions (PAFs) were calculated for modifiable risk factors. Weekly caffeine consumption (adjusted odds ratio [aOR] 0.77, p < 0.0001) and tobacco use for ≥ 5 years (aOR 0.83, p = 0.0009) were inversely associated with PD, whereas severe head trauma (aOR 1.35), occupational pesticide exposure (aOR 1.42), occupational metal exposure (aOR 1.29), rural living (aOR 1.60), and well water consumption (aOR 1.22) increased PD risk (all p < 0.05). Dose-response relationships were observed. The joint PAF was 13.7% (95% CI 9.8-17.3), with higher estimates in El Salvador, Brazil, Colombia, men, and individuals younger than 60 years. Sensitivity and lag analyses yielded consistent results.

Environmental determinants of Parkinson's disease and attributable burden in Latin America.

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Аннотация