Current neurovascular research · 2026
Serotonergic Regulation of Nicotine Addiction: Receptor-specific Mechanisms and Therapeutic Strategies.
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Tiwari Raj Kumar, Sharma Bhawna, Sharma Anuj Kumar, Pandey Rohit
Аннотация
INTRODUCTION: Nicotine dependence remains a global health burden with high relapse rates despite the availability of pharmacological aids. Emerging evidence implicates serotonin (5- HT) receptors in nicotine addiction and withdrawal.
METHODS: This review synthesizes preclinical and clinical findings on the roles of key 5-HT receptor subtypes-5-HT1A, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, and 5-HT6-in nicotine-related behaviors, with a focus on their therapeutic implications.
RESULTS: Current evidence suggests that specific 5-HT receptors contribute differentially to nicotine dependence and withdrawal. Selective Serotonin Reuptake Inhibitors (SSRIs) have shown limited clinical efficacy, while selective targeting of receptor subtypes, particularly 5-HT2C, demonstrates more consistent benefits in reducing nicotine-seeking and relapse.
DISCUSSION: Serotonergic mechanisms play a critical role in nicotine dependence. Targeted modulation of 5-HT receptor subtypes, especially 5-HT2C, may offer promising avenues for developing more effective smoking cessation therapies.
CONCLUSION: Higher SUA/SCr levels were associated with better prognosis in females.
METHODS: This review synthesizes preclinical and clinical findings on the roles of key 5-HT receptor subtypes-5-HT1A, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, and 5-HT6-in nicotine-related behaviors, with a focus on their therapeutic implications.
RESULTS: Current evidence suggests that specific 5-HT receptors contribute differentially to nicotine dependence and withdrawal. Selective Serotonin Reuptake Inhibitors (SSRIs) have shown limited clinical efficacy, while selective targeting of receptor subtypes, particularly 5-HT2C, demonstrates more consistent benefits in reducing nicotine-seeking and relapse.
DISCUSSION: Serotonergic mechanisms play a critical role in nicotine dependence. Targeted modulation of 5-HT receptor subtypes, especially 5-HT2C, may offer promising avenues for developing more effective smoking cessation therapies.
CONCLUSION: Higher SUA/SCr levels were associated with better prognosis in females.