Addictive behaviors · 2026
Clinical effects of pharmacological and electronic cigarette interventions for smoking cessation in pregnancy: a systematic review and network meta-analysis.
СтатьяСистематический обзорNetwork Meta-AnalysisНазвание и аннотация: Перевод в очереди
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Thimkorn Phiyanuch, Booncharoen Chimbun, Chaipitak Panitnan, Wiengkeaw Ployvarin, Thananithisak Chuanchom, Boonpattharatthiti Kansak, Dhippayom Teerapon
Аннотация
BACKGROUND: Smoking during pregnancy adversely affects both mothers and fetuses. This study aimed to evaluate the clinical effects of pharmacological and electronic cigarette (E-cigarette) interventions in supporting smoking cessation among pregnant women.
METHODS: PubMed, EMBASE, CENTRAL, and EBSCO Open Dissertations were searched from inception to December 2024. Randomized controlled trials (RCTs) assessing pharmacotherapies or E-cigarette for smoking cessation during pregnancy were included. Quality of included RCTs was evaluated using the Cochrane risk of bias tool for randomized trials (RoB2). Pooled effects were measured using a random-effects model. The surface under the cumulative ranking curve (SUCRA) were used to rank intervention effects.
RESULTS: Of 1,720 articles, 11 RCTs (n = 4,065) were included. One trial had a low risk of bias, three had some concerns, and six had a high risk. Both the combined use of nicotine patch and gum (relative risk [RR] 3.22; 95% confidence interval [CI]: 1.40, 7.39) and E-cigarette (RR 1.81; 95%CI: 1.11, 2.93) significantly improved point prevalence abstinence compared to usual care, with SUCRA values of 97.0% and 81.3%, respectively. Nicotine gum was significantly associated with higher birthweight (mean difference [MD] 337.00; 95% CI: 103.18, 570.82) and a lower risk of preterm birth compared to usual care (RR 0.39; 95% CI: 0.17, 0.91).
CONCLUSIONS: The combination of a nicotine patch and gum and E-cigarette use are effective for smoking cessation in pregnant women. However, these findings were based on a limited number of studies, and further high-quality randomized controlled trials are needed to confirm their effectiveness.
METHODS: PubMed, EMBASE, CENTRAL, and EBSCO Open Dissertations were searched from inception to December 2024. Randomized controlled trials (RCTs) assessing pharmacotherapies or E-cigarette for smoking cessation during pregnancy were included. Quality of included RCTs was evaluated using the Cochrane risk of bias tool for randomized trials (RoB2). Pooled effects were measured using a random-effects model. The surface under the cumulative ranking curve (SUCRA) were used to rank intervention effects.
RESULTS: Of 1,720 articles, 11 RCTs (n = 4,065) were included. One trial had a low risk of bias, three had some concerns, and six had a high risk. Both the combined use of nicotine patch and gum (relative risk [RR] 3.22; 95% confidence interval [CI]: 1.40, 7.39) and E-cigarette (RR 1.81; 95%CI: 1.11, 2.93) significantly improved point prevalence abstinence compared to usual care, with SUCRA values of 97.0% and 81.3%, respectively. Nicotine gum was significantly associated with higher birthweight (mean difference [MD] 337.00; 95% CI: 103.18, 570.82) and a lower risk of preterm birth compared to usual care (RR 0.39; 95% CI: 0.17, 0.91).
CONCLUSIONS: The combination of a nicotine patch and gum and E-cigarette use are effective for smoking cessation in pregnant women. However, these findings were based on a limited number of studies, and further high-quality randomized controlled trials are needed to confirm their effectiveness.