Drug and alcohol dependence · 2025
Cannabis use among adults who smoke tobacco: Relations with switching from combusted cigarettes to e-cigarettes or very low nicotine cigarettes.
Клиническое исследование II фазыСтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Piper Megan E, Kaye Jesse T, Piasecki Thomas M, Yang James J, Buu Anne
Аннотация
INTRODUCTION: Evidence is mixed regarding whether cannabis use impairs tobacco smoking cessation. This study tests the hypothesis that people who co-use tobacco and cannabis are less likely to switch to an alternative tobacco product when asked to do so.
STUDY DESIGN: Secondary data analysis of a mixed design with a within-subjects factor (active nicotine patch vs. placebo patch) and a between-subjects factor (study product). Participants sampled their assigned study product for 1 week, then were asked not to smoke their usual brand cigarettes and use only their study product and the study patches for 1 week (a switch week). A washout week was followed by a second switch week during which participants used the other patch type.
SETTING/PARTICIPANTS: Research office. Adults not motivated to quit smoking who smoke ≥ 5 cigarettes/day.
INTERVENTION: Study products (very low nicotine cigarettes [VLNCs], e-cigarettes or no product) were provided for 4 weeks and 1 week of active nicotine patches and 1 week of placebo patches were provided in double-blind and counterbalanced fashion, for the switch weeks.
MAIN OUTCOME MEASURES: Number of usual brand cigarettes smoked during the switch weeks.
RESULTS: Data collected September 2019-June 2022 and analyzed November-December 2024. Participants who reported past 30-day co-use of cannabis at baseline (n = 56) smoked significantly more usual brand cigarettes during switch weeks than those who did not co-use (n = 104; p = .03) and were less likely to make a tobacco cessation attempt (p < .05).
CONCLUSIONS: Cannabis use is associated with less switching from cigarettes to VLNCs or e-cigarettes.
TRIAL REGISTRATION: Clinicaltrials.gov (NCT04084210).
STUDY DESIGN: Secondary data analysis of a mixed design with a within-subjects factor (active nicotine patch vs. placebo patch) and a between-subjects factor (study product). Participants sampled their assigned study product for 1 week, then were asked not to smoke their usual brand cigarettes and use only their study product and the study patches for 1 week (a switch week). A washout week was followed by a second switch week during which participants used the other patch type.
SETTING/PARTICIPANTS: Research office. Adults not motivated to quit smoking who smoke ≥ 5 cigarettes/day.
INTERVENTION: Study products (very low nicotine cigarettes [VLNCs], e-cigarettes or no product) were provided for 4 weeks and 1 week of active nicotine patches and 1 week of placebo patches were provided in double-blind and counterbalanced fashion, for the switch weeks.
MAIN OUTCOME MEASURES: Number of usual brand cigarettes smoked during the switch weeks.
RESULTS: Data collected September 2019-June 2022 and analyzed November-December 2024. Participants who reported past 30-day co-use of cannabis at baseline (n = 56) smoked significantly more usual brand cigarettes during switch weeks than those who did not co-use (n = 104; p = .03) and were less likely to make a tobacco cessation attempt (p < .05).
CONCLUSIONS: Cannabis use is associated with less switching from cigarettes to VLNCs or e-cigarettes.
TRIAL REGISTRATION: Clinicaltrials.gov (NCT04084210).