NPJ precision oncology · 2024
Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma.
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Viet Chi T, Asam Kesava R, Yu Gary, Dyer Emma C, Kochanny Sara, Thomas Carissa M, Callahan Nicholas F, Morlandt Anthony B, Cheng Allen C, Patel Ashish A, Roden Dylan F, Young Simon, Melville James, Shum Jonathan, Walker Paul C, Nguyen Khanh K, Kidd Stephanie N, Lee Steve C, Folk Gretchen S, Viet Dan T, Grandhi Anupama, Deisch Jeremy, Ye Yi, Momen-Heravi Fatemeh, Pearson Alexander T, Aouizerat Bradley E
Аннотация
Oral squamous cell carcinoma (OSCC) biomarker studies rarely employ multi-omic biomarker strategies and pertinent clinicopathologic characteristics to predict mortality. In this study we determine for the first time a combined epigenetic, gene expression, and histology signature that differentiates between patients with different tobacco use history (heavy tobacco use with ≥10 pack years vs. no tobacco use). Using The Cancer Genome Atlas (TCGA) cohort (n = 257) and an internal cohort (n = 40), we identify 3 epigenetic markers (GPR15, GNG12, GDNF) and 13 expression markers (IGHA2, SCG5, RPL3L, NTRK1, CD96, BMP6, TFPI2, EFEMP2, RYR3, DMTN, GPD2, BAALC, and FMO3), which are dysregulated in OSCC patients who were never smokers vs. those who have a ≥ 10 pack year history. While mortality risk prediction based on smoking status and clinicopathologic covariates alone is inaccurate (c-statistic = 0.57), the combined epigenetic/expression and histologic signature has a c-statistic = 0.9409 in predicting 5-year mortality in OSCC patients.