Journal of psychiatric research · 2023
Tobacco use modify exon IV BDNF gene methylation levels in depression.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Quaioto Bárbara Risse, Borçoi Aline Ribeiro, Mendes Suzanny Oliveira, Doblas Paola Cerbino, Dos Santos Vieira Tamires, Arantes Moreno Ivana Alece, Dos Santos Joaquim Gasparini, Hollais André Willian, Olinda Amanda Sgrancio, de Souza Marcele Lorentz Mattos, Freitas Flávia Vitorino, Pinheiro Júlia Assis, Cunha Ester Ribeiro, Sorroche Bruna Pereira, Arantes Lídia Maria Rebolho Batista, Álvares-da-Silva Adriana Madeira
Аннотация
This study aimed to investigate BDNF gene methylation in individuals with depression based on tobacco use. Therefore, 384 adults from southeastern Brazil were recruited to assess depression, socioeconomic status, lifestyle, and methylation by pyrosequencing exon IV promoter region of the BDNF gene. The Generalized Linear Model (GzLM) was used to check the effect of depression, tobacco, and the interaction between depression and tobacco use in methylation levels. In addition, the Kruskal-Wallis test, followed by Dunn's post hoc test, was used to compare methylation levels. Interaction between depression and tobacco use was significant at levels of BDNF methylation in the CpG 5 (p = 0.045), 8 (p = 0.016), 9 (p = 0.042), 10 (p = 0.026) and mean 5-11 (p < 0.001). Dunn's post hoc test showed that individuals with depression and tobacco use compared to those with or without depression who did not use tobacco had lower levels of BDNF methylation in CpG 5, 6, 7, 8, 9, 11, and mean 5-11. Therefore, we suggest that tobacco use appears to interfere with BDNF gene methylation in depressed individuals.