Frontiers in neurology · 2025
Treating status epilepticus in clinical practice-a multi-national survey in Germany, Austria, and Switzerland.
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Möller Leona, Fisch Urs, Habermehl Lena, Jünemann Clara
Аннотация
BACKGROUND: Status epilepticus (SE) is a life-threatening neurological emergency, and exhibits significant variability in clinical management despite established guidelines. This study evaluates current practices across German speaking countries.
METHODS: A web-based survey (December 2023-May 2024) assessed SE treatment strategies among 83 neurologists and neurointensivists from Germany, Austria, and Switzerland. Cases were presented to analyze diagnostic and therapeutic preferences.
RESULTS: The preferred benzodiazepine for first line treatment was lorazepam, chosen by 71.6% of the respondents. In the case of established SE, 35.4% chose levetiracetam as the preferred ASM. Propofol in combination with sufentanil/fentanyl was the preferred anesthetic of choice in 65.4% of respondents. For super-refractory status epilepticus (SRSE), 41.5% prefer to add further ASM, with valproic acid (67.1%), and lacosamide (64.5%) being the most frequently selected. Only 31.8% reported that their emergency services have a standard operating procedure (SOP) for SE treatment, and the choice of the preferred benzodiazepine varied in the preclinical setting, with midazolam being the most commonly used. 1) First-line therapy: Lorazepam (71.6% in-hospital), midazolam (50% prehospital), 2) Second-line therapy: Levetiracetam (35.4%) and lacosamide (13.4%) were the most common choices, 3) Refractory SE: Propofol with opioids (65.4%) were preferred for anesthesia, 4) Prehospital care: 31.8% of emergency services lacked standardized protocols; midazolam dosing varied widely (2-10 mg).
DIAGNOSTICS: Laboratory testing was universal (96.9%), but MR-imaging (10%) and clinical use of prognostic scores (6.2%) were underutilized.
CONCLUSION: This survey highlights the variability in clinical practice for managing status epilepticus in German-speaking countries. Persistent heterogeneity in SE management underscores the need for standardized protocols, particularly in prehospital care and refractory SE therapy.
METHODS: A web-based survey (December 2023-May 2024) assessed SE treatment strategies among 83 neurologists and neurointensivists from Germany, Austria, and Switzerland. Cases were presented to analyze diagnostic and therapeutic preferences.
RESULTS: The preferred benzodiazepine for first line treatment was lorazepam, chosen by 71.6% of the respondents. In the case of established SE, 35.4% chose levetiracetam as the preferred ASM. Propofol in combination with sufentanil/fentanyl was the preferred anesthetic of choice in 65.4% of respondents. For super-refractory status epilepticus (SRSE), 41.5% prefer to add further ASM, with valproic acid (67.1%), and lacosamide (64.5%) being the most frequently selected. Only 31.8% reported that their emergency services have a standard operating procedure (SOP) for SE treatment, and the choice of the preferred benzodiazepine varied in the preclinical setting, with midazolam being the most commonly used. 1) First-line therapy: Lorazepam (71.6% in-hospital), midazolam (50% prehospital), 2) Second-line therapy: Levetiracetam (35.4%) and lacosamide (13.4%) were the most common choices, 3) Refractory SE: Propofol with opioids (65.4%) were preferred for anesthesia, 4) Prehospital care: 31.8% of emergency services lacked standardized protocols; midazolam dosing varied widely (2-10 mg).
DIAGNOSTICS: Laboratory testing was universal (96.9%), but MR-imaging (10%) and clinical use of prognostic scores (6.2%) were underutilized.
CONCLUSION: This survey highlights the variability in clinical practice for managing status epilepticus in German-speaking countries. Persistent heterogeneity in SE management underscores the need for standardized protocols, particularly in prehospital care and refractory SE therapy.