Effect of Dimephosphone on the Mechanical Activity of the Bladder in Rats with a Model of Autism.

The valproate model of autism was used to evaluate the effect of a course of dimephosphone administration (intragastric, 50 mg/kg, 30 days) on contractions of the isolated bladder of rats induced by application of carbacholine (10-7-10-5 M), α,β-methylene-ATP (10-7-10-5 M), and stimulation with an electric field of different frequencies (1-20 Hz). In rats with the valproate model of autism, the strength of carbacholine-induced bladder contractions was significantly higher than in control (intact) rats. Against the background of dimephosphone administration, carbacholine-induced contractions reached the control level. Similar results were obtained with electric field stimulation. However, when evaluating the effect of dimephosphone on bladder contractions caused by α,β-methylene-ATP, no significant changes were found. Dimephosphone, when administered in a course, normalizes bladder contractility in rats with the valproate model of autism.