Bugs Bugging the Body and the Brain: A Case of a Bed Bug Infestation Progressing to Delusions of Parasitosis Treated With Clozapine.

Delusions of parasitosis, also known as delusional parasitosis or Ekbom syndrome, is a rare psychiatric disorder characterized by a fixed belief in a bug infestation, despite the absence of clinical evidence. It often co-occurs with other psychiatric conditions such as depression, anxiety, and schizophrenia. In this case, a 50-year-old man with bipolar-type schizoaffective disorder developed delusional parasitosis after a bed bug infestation in his group home. His inadequate adherence to prescribed medications likely exacerbated his symptoms. Treatment involved the consistent administration of clozapine and valproic acid, with dosage adjustments and close monitoring by a psychiatric team. Notably, clozapine's successful role in this case is unique, as delusional parasitosis is typically treated with second-generation atypical antipsychotics.