Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pekoz Mehmet Taylan, Aslan-Kara Kezban, Tekin Betül, Gurses Candan, Yeni Seher Naz, Bozdemir Hacer, Keskin-Guler Selda, Ataklı Dilek, Gul Gunay, Eren Fulya, Sarı Hüseyin, Gul Zeynep Baştug, Ceyhan-Dirican Ayten, Genc Fatma, Bicer-Gomceli Yasemin, Ozkara Cigdem, Delil Sakir, Atalar Arife Cimen, Bebek Nerses, Baykan Betül, Bora İbrahim, Bican-Demir Aylin, Mısırlı Cemile Handan, Tutkavul Kemal, Velioglu Sibel K, Ilhan-Algin Demet, Erdinc Oguz, Saygi Serap, Tezer-Fılık Irsel, Apaydın-Dogan Ebru, Akyol Ali, Kamisli Ozden, Yalcın A Destina, Cakmak Gonul, Ersoy Alevtina, Ustun-Ozek Sibel, Halac Gulistan, Kutlu Gulnihal, Tantik-Pak Aygul, Yücel Sevinc P
Аннотация
METHODS: PWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee. The newborns were examined by a neonatologist after delivery and at 1 and 3 months postpartum.
RESULTS: Of the infants of 759 PWWE, 7.2% had CMs, with 5.6% having major CMs. Polytherapy, monotherapy, and no medications were received by 168 (22.1%), 548 (72.2 %), and 43 (5.7 %) patients, respectively. CMs were detected at an incidence of 2.3% in infants of PWWE who did not receive medication, 5.7% in infants of PWWE who received monotherapy, and 13.7% in infants of PWWE who received polytherapy. The risk of malformation was 2.31-fold (95% confidence interval (CI): 1.48-4.61, p < .001) higher in infants of PWWE who received polytherapy. Levetiracetam was the most frequently used seizure medication as monotherapy, with the highest incidence of CMs occurring with valproic acid (VPA) use (8.5%) and the lowest with lamotrigine use (2.1%). The incidence of CMs was 5% at a carbamazepine dose <700 mg, 10% at a carbamazepine dose ≥700 mg, 5.5% at a VPA dose <750 mg, and 14.8% at a VPA dose ≥750 mg. Thus the risk of malformation increased 2.33 times (p = .041) in infants of PWWE receiving high-dose ASMs.
SIGNIFICANCE: Birth outcomes of PWWE receiving and not receiving ASMs were evaluated. The risk of CMs occurrence was higher, particularly in infants of PWWE using VPA and receiving polytherapy. The incidence of CMs was found to be lower in infants of PWWE receiving lamotrigine.