[Tobacco dependence, anxiety, and depression].

Anxiety and depression are often comorbid with tobacco dependence, partly reflecting attempts to self-medicate symptoms with nicotine. However, a stronger contributor to the association appears to be neurotoxic effects of nicotine and tobacco smoke, which promote the development/worsening of these disorders, especially if smoking starts during adolescence. Notably, prolonged smoking cessation improves symptoms, and the transient withdrawal reactions can be alleviated by smoking cessation agents. This review finds that focused treatment of anhedonia and distress/anxiety sensitivity improves cessation outcomes.