Impact of Assertive Outreach, Individual Involvement, and Significant Other Involvement on XR-NTX Adherence.

BACKGROUND AND

OBJECTIVES

The current study investigates the roles of assertive outreach, individual participant involvement, and treatment significant other (TSO) involvement through the Medication Adherence Therapy: Psychosocial Leverage Using a Significant other (MAT-PLUS) intervention on extended-release naltrexone (XR-NTX) adherence for the treatment of opioid and/or alcohol use disorder (OUD/AUD).

METHODS

Participants receiving XR-NTX for OUD and/or AUD received 16 weeks of the MAT-PLUS intervention through a prior randomized controlled trial (RCT). Logs tracked XR-NTX adherence, treatment team outreach, and participant/family communications and sessions.

RESULTS

Of the contact types examined, only the number of family sessions attended significantly predicted next XR-NTX dose receipt (OR = 8.74, 95% CI [1.84, 54.41]) in n = 12 participants.

CONCLUSIONS

Family involvement is an important component of OUD/AUD treatment that may improve XR-NTX adherence.

CLINICAL TRIAL REGISTRATION: Treatment of opioid use: Medication Adherence Therapy (MAT-PLUS), https://clinicaltrials.gov/study/NCT03567356?term=MAT-PLUS&rank=1, NCT03567356.