Astrocytic connexins in alcohol use disorder: mechanisms of neuroinflammation and therapeutic potential.

Astrocytes are critical regulators of brain homeostasis and are known to be disrupted during alcohol use disorder (AUD). Here, we describe what is known about astrocytic dysfunction in AUD and the emerging literature supporting a mechanistic link to connexins in the pathophysiology of this disorder. We integrate what is known in the current literature and highlight areas where a lack of evidence leads to inconclusive interpretations. Overall, this is a comprehensive review of astrocytes and connexins in AUD, providing ideas and insights to basic and clinical audiences interested in pursuing future therapeutic mechanisms in AUD.