Awareness and vaccination willingness of middle-aged and elderly individuals in Southwest China toward to herpes zoster vaccine.

The incidence of herpes zoster is increasing in China's aging society, and vaccination is the most effective preventive measure. However, vaccine hesitancy is a major obstacle. A survey was conducted among individuals aged 50 and above in Southwest China to assess their awareness and willingness to vaccinate against herpes zoster. The 3C model was used to analyze factors influencing vaccine hesitancy. Among 3,007 participants, vaccine hesitancy ranged from 62.7% to 68.9% across different regions, and 62.5% to 64.7% had no knowledge of the herpes zoster vaccine. Statistical analysis showed that higher disposable income, better knowledge of herpes zoster and the vaccine were associated with lower vaccine hesitancy. According to the 3C model, lower confidence in vaccines, higher complacency, and perceived inconvenience of vaccination were linked to increased hesitancy. This study found low awareness and willingness to vaccinate among middle-aged and older adults in Southwest China. It provided insights into the causes of vaccine hesitancy, which could inform the development of effective vaccination strategies to reduce herpes zoster incidence in the elderly.