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DOI 10.1016/j.ortho.2018.01.021

Медицинская библиотека · International orthodontics · 2018

Decreased bone density induced by antiepileptic drugs can cause accelerated orthodontic tooth movement in male Wistar rats.

Akhoundi Mohammad Sadegh Ahmad, Sheikhzadeh Sedigheh, Mirhashemi Amirhossein, Ansari Elahe, Kheirandish Yasaman, Allaedini Mozhgan, Dehpour Ahmadreza

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Аннотация

PURPOSE: The aim of the present study was to evaluate the effect of the carbamazepine and valproic acid on orthodontic tooth movement in male Wistar rats.

METHODS

Evaluation of tooth movement after 21 days of drugs infusion was carried out by feeler gauge. Bone densitometry on lateral cephalograms was conducted on days 1 and 21. After dissection of the maxillae, histologic parameters were evaluated.

RESULTS

Orthodontic tooth movement was accelerated in experimental groups rather than controls. Optical density was significantly increased in these groups. In histologic sections, mesioapical portion of the PDL (Periodontal Ligament) was wider in experimental groups. Also, distoapical portion of the PDL was wider only in valproic acid group.

CONCLUSION

Valproic acid and carbamazepine can decrease the bone density which may induce the accelerated orthodontic tooth movement in rats.

Для цитирования: Akhoundi Mohammad Sadegh Ahmad, Sheikhzadeh Sedigheh, Mirhashemi Amirhossein, Ansari Elahe, Kheirandish Yasaman, Allaedini Mozhgan, Dehpour Ahmadreza. Decreased bone density induced by antiepileptic drugs can cause accelerated orthodontic tooth movement in male Wistar rats.. International orthodontics. 2018. DOI: 10.1016/j.ortho.2018.01.021.

Предметные рубрики MeSH

AnimalsAnticonvulsantsBone DensityCarbamazepineMaleRats, WistarTooth Movement TechniquesValproic Acid
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