Journal of studies on alcohol and drugs · 2025
Ketogenic Diet Reduces Alcohol Consumption and Improves Memory and Sociability in Mice.
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Bechard Allison R, Storie Kayla, Grzeskowiak Abigail, Forcier Madison, Nunez Yovanka, Brambhatt Dhavan, Azurin Sophia, Connell Riley, Kamel Jana
Аннотация
OBJECTIVE: Alcohol use disorder is highly prevalent, with known associations to poor health and memory. Diet interventions are a useful tool that can help many, as they are relatively non-invasive and accessible. The ketogenic diet is a high-fat, low-carbohydrate diet that has been used for decades to reduce seizures in children with epilepsy. In the current study, the effects of 3 weeks of a ketogenic diet on alcohol use and anxiety, post-alcohol anxiety, sociability, and memory were assessed in C57BL/6J mice.
METHOD: In Experiments 1 and 1a, mice were allowed to drink alcohol for 8 weeks using the intermittent drinking-in-the-dark paradigm. Across the last 3 weeks of drinking, mice were fed either a ketogenic diet or a standard chow diet and tested for performance in a Barnes maze. In Experiment 2, mice were fed either a ketogenic diet or a standard diet for 3 weeks and observed for anxiety and social behaviors, and memory. Experiment 2a extended this work using a small number of male mice that were injected with alcohol for 1 week before behavioral assessment.
RESULTS: Overall, our findings suggest a therapeutic effect of the ketogenic diet on alcohol consumption and post-alcohol deficits.
CONCLUSIONS: Benefits were independent of effects on generalized anxiety yet support a more specific effect of the ketogenic diet to increase exploration and reduce behavioral inhibition. This study did not investigate the neurobiology underlying these effects, and future research is now needed.
METHOD: In Experiments 1 and 1a, mice were allowed to drink alcohol for 8 weeks using the intermittent drinking-in-the-dark paradigm. Across the last 3 weeks of drinking, mice were fed either a ketogenic diet or a standard chow diet and tested for performance in a Barnes maze. In Experiment 2, mice were fed either a ketogenic diet or a standard diet for 3 weeks and observed for anxiety and social behaviors, and memory. Experiment 2a extended this work using a small number of male mice that were injected with alcohol for 1 week before behavioral assessment.
RESULTS: Overall, our findings suggest a therapeutic effect of the ketogenic diet on alcohol consumption and post-alcohol deficits.
CONCLUSIONS: Benefits were independent of effects on generalized anxiety yet support a more specific effect of the ketogenic diet to increase exploration and reduce behavioral inhibition. This study did not investigate the neurobiology underlying these effects, and future research is now needed.