Emerging infectious diseases · 2021
Epidemiologic History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Gräf Tiago, Vazquez Cynthia, Giovanetti Marta, de Bruycker-Nogueira Fernanda, Fonseca Vagner, Claro Ingra Morales, de Jesus Jaqueline Goes, Gómez Andrea, Xavier Joilson, de Mendonça Marcos Cesar Lima, Villalba Shirley, Torales Juan, Gamarra Maria Liz, Thézé Julien, de Filippis Ana Maria Bispo, Azevedo Vasco, de Oliveira Tulio, Franco Leticia, de Albuquerque Carlos F Campelo, Irala Sandra, Holmes Edward Charles, Méndez Rico Jairo Andrés, Alcantara Luiz Carlos Junior
Аннотация
Paraguay has been severely affected by emergent Zika and chikungunya viruses, and dengue virus is endemic. To learn more about the origins of genetic diversity and epidemiologic history of these viruses in Paraguay, we deployed portable sequencing technologies to strengthen genomic surveillance and determine the evolutionary and epidemic history of arthropod-borne viruses (arboviruses). Samples stored at the Paraguay National Central Laboratory were sequenced and subjected to phylogenetic analysis. Among 33 virus genomes generated, we identified 2 genotypes of chikungunya and 2 serotypes of dengue virus that circulated in Paraguay during 2014-2018; the main source of these virus lineages was estimated to be Brazil. The evolutionary history inferred by our analyses precisely matched the available travel history of the patients. The genomic surveillance approach used was valuable for describing the epidemiologic history of arboviruses and can be used to determine the origins and evolution of future arbovirus outbreaks.