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Nature communications · 2021

Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Adelino Talita Émile Ribeiro, Giovanetti Marta, Fonseca Vagner, Xavier Joilson, de Abreu Álvaro Salgado, do Nascimento Valdinete Alves, Demarchi Luiz Henrique Ferraz, Oliveira Marluce Aparecida Assunção, da Silva Vinícius Lemes, de Mello Arabela Leal E Silva, Cunha Gabriel Muricy, Santos Roselene Hans, de Oliveira Elaine Cristina, Júnior Jorge Antônio Chamon, de Melo Iani Felipe Campos, de Filippis Ana Maria Bispo, de Abreu André Luiz, de Jesus Ronaldo, de Albuquerque Carlos Frederico Campelo, Rico Jairo Mendez, do Carmo Said Rodrigo Fabiano, Silva Joscélio Aguiar, de Moura Noely Fabiana Oliveira, Leite Priscila, Frutuoso Lívia Carla Vinhal, Haddad Simone Kashima, Martínez Alexander, Barreto Fernanda Khouri, Vazquez Cynthia Carolina, da Cunha Rivaldo Venâncio, Araújo Emerson Luiz Lima, de Oliveira Tosta Stephane Fraga, de Araújo Fabri Allison, Chalhoub Flávia Löwen Levy, da Silva Lemos Poliana, de Bruycker-Nogueira Fernanda, de Castro Lichs Gislene Garcia, Zardin Marina Castilhos Souza Umaki, Segovia Fátima María Cardozo, Gonçalves Crhistinne Cavalheiro Maymone, Grillo Zoraida Del Carmen Fernandez, Slavov Svetoslav Nanev, Pereira Luiz Augusto, Mendonça Ana Flávia, Pereira Felicidade Mota, de Magalhães Jurandy Júnior Ferraz, Dos Santos Júnior Agenor de Castro Moreira, de Lima Maricélia Maia, Nogueira Rita Maria Ribeiro, Góes-Neto Aristóteles, de Carvalho Azevedo Vasco Ariston, Ramalho Dario Brock, Oliveira Wanderson Kleber, Macario Eduardo Marques, de Medeiros Arnaldo Correia, Pimentel Victor, Latin American Genomic Surveillance Arboviral Network, Holmes Edward C, de Oliveira Tulio, Lourenço José, Alcantara Luiz Carlos Junior

Аннотация

Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases. Using both phylogenetic and epidemiological models we retrospectively reconstructed the recent transmission history of DENV1-2. Phylogenetic analysis revealed complex patterns of transmission, with both lineage co-circulation and replacement. We identified two lineages within the DENV2 BR-4 clade, for which we estimated the effective reproduction number and pattern of seasonality. Overall, the surveillance outputs and training initiative described here serve as a proof-of-concept for the utility of real-time portable sequencing for research and local capacity building in the genomic surveillance of emerging viruses.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты