Epilepsia · 2013
Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Møller Rikke S, Weber Yvonne G, Klitten Laura L, Trucks Holger, Muhle Hiltrud, Kunz Wolfram S, Mefford Heather C, Franke Andre, Kautza Monika, Wolf Peter, Dennig Dieter, Schreiber Stefan, Rückert Ina-Maria, Wichmann H-Erich, Ernst Jan P, Schurmann Claudia, Grabe Hans J, Tommerup Niels, Stephani Ulrich, Lerche Holger, Hjalgrim Helle, Helbig Ingo, Sander Thomas, EPICURE Consortium
Аннотация
PURPOSE: Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs).
METHODS: We screened for deletions involving the NRXN1 gene in 1,569 patients with IGE and 6,201 controls using high-density oligonucleotide microarrays.
KEY FINDINGS: We identified exon-disrupting deletions of NRXN1 in 5 of 1,569 patients with IGE and 2 of 6,201 control individuals (p = 0.0049; odds ratio (OR) 9.91, 95% confidence interval (CI) 1.92-51.12). A complex familial segregation pattern in the IGE families was observed, suggesting that heterozygous NRXN1 deletions are susceptibility variants. Intriguingly, we identified a second large copy number variant in three of five index patients, supporting an involvement of heterogeneous susceptibility alleles in the etiology of IGE.
SIGNIFICANCE: We conclude that exon-disrupting deletions of NRXN1 represent a genetic risk factor in the genetically complex predisposition of common IGE syndromes.
METHODS: We screened for deletions involving the NRXN1 gene in 1,569 patients with IGE and 6,201 controls using high-density oligonucleotide microarrays.
KEY FINDINGS: We identified exon-disrupting deletions of NRXN1 in 5 of 1,569 patients with IGE and 2 of 6,201 control individuals (p = 0.0049; odds ratio (OR) 9.91, 95% confidence interval (CI) 1.92-51.12). A complex familial segregation pattern in the IGE families was observed, suggesting that heterozygous NRXN1 deletions are susceptibility variants. Intriguingly, we identified a second large copy number variant in three of five index patients, supporting an involvement of heterogeneous susceptibility alleles in the etiology of IGE.
SIGNIFICANCE: We conclude that exon-disrupting deletions of NRXN1 represent a genetic risk factor in the genetically complex predisposition of common IGE syndromes.
Предметные рубрики MeSH
AdultAge of OnsetAnticonvulsantsCalcium-Binding ProteinsCase-Control StudiesCell Adhesion Molecules, NeuronalDNA Copy Number VariationsElectroencephalographyEpilepsy, GeneralizedExonsFamilyFemaleFructoseGene DeletionGenotypeHumansInfantLamotrigineMaleMicroarray AnalysisMiddle AgedNerve Tissue ProteinsNeural Cell Adhesion MoleculesNeuropsychological TestsOdds RatioPedigreeTopiramateTriazinesValproic Acid