Psychopharmacology · 2010
Modulation of human motor cortex excitability by valproate.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zunhammer Matthias, Langguth Berthold, Landgrebe Michael, Frank Elmar, Müller Sabine, Burger Julia, Sand Philipp G, Eichhammer Peter, Hajak Göran
Аннотация
RATIONALE: Valproate is widely used in the treatment of epilepsy, bipolar disorder, and chronic pain disorders, but its exact mechanisms of action is still incompletely understood.
OBJECTIVES: Here we used transcranial magnetic stimulation to explore effects of a single dose of 800 mg valproate on motor cortex excitability in healthy volunteers.
METHODS: Motor threshold, peripheral maximum M-wave, cortical silent period short intracortical inhibition, intracortical facilitation, and motor evoked potential recruitment were assessed before and 1.5 h after the administration of valproate in 15 (eight male, seven female) healthy volunteers.
RESULTS: None of the measures of cortical excitability were found to be altered significantly after valproate.
CONCLUSION: These results are in line with previous findings of unaffected intracortical excitability after a single dose of valproate, suggesting that valproate's immediate in vivo actions do not resemble the effects of classic GABAergic compounds.
OBJECTIVES: Here we used transcranial magnetic stimulation to explore effects of a single dose of 800 mg valproate on motor cortex excitability in healthy volunteers.
METHODS: Motor threshold, peripheral maximum M-wave, cortical silent period short intracortical inhibition, intracortical facilitation, and motor evoked potential recruitment were assessed before and 1.5 h after the administration of valproate in 15 (eight male, seven female) healthy volunteers.
RESULTS: None of the measures of cortical excitability were found to be altered significantly after valproate.
CONCLUSION: These results are in line with previous findings of unaffected intracortical excitability after a single dose of valproate, suggesting that valproate's immediate in vivo actions do not resemble the effects of classic GABAergic compounds.