Drug design, development and therapy · 2018
The retinoprotective role of phenytoin.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Bartollino Silvia, Chiosi Flavia, di Staso Silvio, Uva Maurizio, Pascotto Arduino, Rinaldi Michele, Hesselink Jan M Keppel, Costagliola Ciro
Аннотация
Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.