Медицинская библиотека · Critical care (London, England) · 2026

10 years trends and hospitalization outcomes of non-neonatal tetanus: a large-scale multicenter retrospective study in China.

Liu Chunxin, Lei Minli, Chen Jingjing, Huang Miaoting, Lu Yaxin, Chen Yueming, Wu Dengfeng, Tan Xingcai, Liang Yuqiang, Zhao Xianwu, He Guowei, Yu Long, Huang Mingming, He Tianrong, Yang Chi, Zhang Gengwei, Xu Jing, Liao Renfeng, Lu Shaoyun, He Shufa, Qiu Huizhong, Chen Yingjie, Zhao Zhong, Liang Jinrong, Xu Fuxing, Liu Shuyan, He Yongxiang, Lv Yuanjun, Yuan Zeqiang, He Huangyang, Deng Hong, Jiang Yingbo, Huang Weibin, Zhuang Xianrui, Qiu Xiaoxin, Liu Qinhai, Huang Rui, Yang Ke, Peng Yuntao, Ye Yi, Ke Jiajie, Dou Qingli, Deng Wenlong, Zhang Haobo, Kang Xiuqun, Liu Nan, Chen Jun, Zhu Wenjian, Song Fengqing, Liu Yang, Xie Shengnan, Gu Haiyu, Shao Wenming, Luo Licheng, Huang Yaowen, Wu Zenglong, Liu Ping, Liao Maoxiang, Ye Shusen, Tu Xusheng, Wu Jianan, Wu Mufu, Chen Yingquan, Zhang Wei, Fu Haiming, Ding Huarong, Shao Xiao, Lou Anni, Chen Yulin, Fan Zhao, Lei Zengliang, Yan Jianhui, Chen Xian, Peng Na, Lv Wen, Feng Ying, Liang Qing, He Mingliang, Huang Zhilin, Li Tao, Li Jun, Fan Wenfeng, Lai Zhiquan, He Yusheng, Zhang Yewen, Qiu Hanzhong, Yu Yang, Huang Yongguang, Liu Dongjian, Quan Weixin, Zhang Huanyao, Li Jifeng, Wu Liping, Yi Tao, Wu Wensheng, Xie Sheng, Huang Wenhui, Yang Yue, Wen Guangshao, He Yan, Wu Jian, Chen Qunlin, Liu Chuming, Hua Zhixue, Yang Xiaoyan, Wang Keke, Hu Jiasong, Mao Changqing, Li Jianfei, Song Ping, Jiang Chunfa, Zhong Weiqin, Li Xiaoyue, Zhang Jialuan, Hu Bei, Tang Youqing, Lian Zhiming, Liu Li, Liu Wenyue, Wu Qihua, Chai Yaling, Lai Xiaoming, Zheng Yong, Lu Yuanwen, Li Dianhong, Zhou Zhipeng, Lin Qiutian, Liang Guangda, Zhu Huayuan, Zhong Feng, Du Mingjun, Huang Yue, Zeng Xingdong, Zhan Huaqing, Wang Fengxi, Yu Wenzhong, Wu Pengcheng, Wang Ruiquan, Liu Bo, Yu Lintao, Chen Chao, Wu Haidong, Wu Zhenggeng, Wang Lanxiang, Zhang Linfeng, Guo Tengfei, Xiao Wenliang, Li Guoyan, Lin Shaoyi, Yan Fuhua, Gao Yufeng, Chen Yukun, Wang Haixia, Chen Ruisui, Gu Donghua, Zheng Weicong, Liang Cong, Zhang Yuetao, Wang Yanli, Feng Xu, Xiao Fuquan, Huang Xuemin, Liao Guisheng, Yuan Yaogen, Deng Shaofeng, Liu Quanle, Zheng Zhenliang, Zhang Yongbiao

СтатьяМногоцентровое исследованиеПеревод в очереди

Аннотация

OBJECTIVES

Non-neonatal tetanus continues to pose a public health challenge in low- and middle-income regions. This study aimed to describe the decade-long profile of non-neonatal tetanus in Guangdong, China, from 2011 to 2021—a period marked by rapid economic development and healthcare system strengthening.

DESIGN

Multicenter, retrospective study.

SETTING

The study was conducted across 159 hospitals in Guangdong, China. PATIENTS: We included patients with a clinical diagnosis of tetanus admitted between 2011 and 2021. A total of 2,567 cases (median age 53 years; 62.1% male) were analyzed. INTERVENTIONS: None. MEASUREMENTS AND MAIN

RESULTS

Data on demographics, vaccination status, clinical severity (Ablett classification), etiology, seasonal trends, critical care utilization, outcomes, and costs were collected. Farmers constituted the largest occupational group (43.7%), and only 2.2% had documented tetanus vaccination. Hospitalizations fluctuated but showed an overall increase, with a rising proportion of severe cases (Ablett grade III/IV). A seasonal peak was observed in August–September. The most common etiology was post-traumatic injury (43.4%). Critical care was frequently required: 25.1% of patients were admitted to the ICU, and 23.8% received mechanical ventilation. Multivariable analysis identified higher Ablett grade, injection drug use, unknown etiology, and comorbidities as independent risk factors for mortality; ICU admission was protective. Case fatality declined significantly from 11.8% in 2012 to 3.5% in 2021, while median hospitalization costs rose substantially.

CONCLUSIONS

This large-scale study reveals a substantial burden of severe non-neonatal tetanus among under-vaccinated adults, persisting despite the region’s economic transition. Case fatality decreased over the study period, likely reflecting improvements in both the accessibility and quality of critical care, albeit with increasing healthcare costs. The association between injection drug use or unknown etiology and mortality warrants heightened clinical vigilance.

Для цитирования: Liu Chunxin, Lei Minli, Chen Jingjing, Huang Miaoting, Lu Yaxin, Chen Yueming, Wu Dengfeng, Tan Xingcai, Liang Yuqiang, Zhao Xianwu, He Guowei, Yu Long, Huang Mingming, He Tianrong, Yang Chi, Zhang Gengwei, Xu Jing, Liao Renfeng, Lu Shaoyun, He Shufa, Qiu Huizhong, Chen Yingjie, Zhao Zhong, Liang Jinrong, Xu Fuxing, Liu Shuyan, He Yongxiang, Lv Yuanjun, Yuan Zeqiang, He Huangyang, Deng Hong, Jiang Yingbo, Huang Weibin, Zhuang Xianrui, Qiu Xiaoxin, Liu Qinhai, Huang Rui, Yang Ke, Peng Yuntao, Ye Yi, Ke Jiajie, Dou Qingli, Deng Wenlong, Zhang Haobo, Kang Xiuqun, Liu Nan, Chen Jun, Zhu Wenjian, Song Fengqing, Liu Yang, Xie Shengnan, Gu Haiyu, Shao Wenming, Luo Licheng, Huang Yaowen, Wu Zenglong, Liu Ping, Liao Maoxiang, Ye Shusen, Tu Xusheng, Wu Jianan, Wu Mufu, Chen Yingquan, Zhang Wei, Fu Haiming, Ding Huarong, Shao Xiao, Lou Anni, Chen Yulin, Fan Zhao, Lei Zengliang, Yan Jianhui, Chen Xian, Peng Na, Lv Wen, Feng Ying, Liang Qing, He Mingliang, Huang Zhilin, Li Tao, Li Jun, Fan Wenfeng, Lai Zhiquan, He Yusheng, Zhang Yewen, Qiu Hanzhong, Yu Yang, Huang Yongguang, Liu Dongjian, Quan Weixin, Zhang Huanyao, Li Jifeng, Wu Liping, Yi Tao, Wu Wensheng, Xie Sheng, Huang Wenhui, Yang Yue, Wen Guangshao, He Yan, Wu Jian, Chen Qunlin, Liu Chuming, Hua Zhixue, Yang Xiaoyan, Wang Keke, Hu Jiasong, Mao Changqing, Li Jianfei, Song Ping, Jiang Chunfa, Zhong Weiqin, Li Xiaoyue, Zhang Jialuan, Hu Bei, Tang Youqing, Lian Zhiming, Liu Li, Liu Wenyue, Wu Qihua, Chai Yaling, Lai Xiaoming, Zheng Yong, Lu Yuanwen, Li Dianhong, Zhou Zhipeng, Lin Qiutian, Liang Guangda, Zhu Huayuan, Zhong Feng, Du Mingjun, Huang Yue, Zeng Xingdong, Zhan Huaqing, Wang Fengxi, Yu Wenzhong, Wu Pengcheng, Wang Ruiquan, Liu Bo, Yu Lintao, Chen Chao, Wu Haidong, Wu Zhenggeng, Wang Lanxiang, Zhang Linfeng, Guo Tengfei, Xiao Wenliang, Li Guoyan, Lin Shaoyi, Yan Fuhua, Gao Yufeng, Chen Yukun, Wang Haixia, Chen Ruisui, Gu Donghua, Zheng Weicong, Liang Cong, Zhang Yuetao, Wang Yanli, Feng Xu, Xiao Fuquan, Huang Xuemin, Liao Guisheng, Yuan Yaogen, Deng Shaofeng, Liu Quanle, Zheng Zhenliang, Zhang Yongbiao. 10 years trends and hospitalization outcomes of non-neonatal tetanus: a large-scale multicenter retrospective study in China.. Critical care (London, England). 2026. DOI: 10.1186/s13054-026-05931-z.

Предметные рубрики MeSH

Humans Retrospective Studies Tetanus China Male Hospitalization Female Middle Aged Adult Aged

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