Recreational nitrous oxide abuse and myeloneuropathy among Vietnamese youth: A descriptive study of 35 cases.

BACKGROUND

Nitrous oxide (N₂O) misuse has become increasingly prevalent among young adults in Vietnam, with growing reports of neurological complications.

METHODS

We conducted a retrospective analysis of 35 patients with N₂O-induced neurotoxicity admitted to Bach Mai Hospital from 2022 to 2024.

RESULTS

Patients were mostly female (65.7 %), median age 22, with students and office workers being the predominant occupations. Neurological symptoms included paresthesias (88.6 %), weakness (82.9 %), and unsteadiness (77.1 %). MRI revealed dorsal column lesions in 60 %. All patients received B12 therapy. Full recovery occurred in 91.4 %; 8.6 % had mild persistent symptoms.

CONCLUSIONS

N₂O misuse is an emerging threat in Vietnam. Despite favorable treatment outcomes, prevention through public education and policy is essential. Our findings contribute important local data to support future regulation and health promotion efforts.