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Outreach has emerged as an essential response to reach marginalised populations and remove barriers to health care. In the field of addiction medicine, this approach has been rethought to address the intertwined vulnerabilities and complex needs of people experiencing marginalisation and drug use. In this context, effective outreach is possible within a strong collaboration between health, social and security actors, and by fully integrating peer support, opening up important and innovative collaborations between these actors to adapt addiction policies and services to the realities on the ground.