How do you Zzz during pregnancy? A brief review of Z-drug use and management of insomnia during pregnancy.

UNLABELLED: Sleep disturbance is highly prevalent during pregnancy, and there are no guidelines clearly appraising pharmacological treatment for insomnia during pregnancy. Furthermore, the data on the efficacy and safety of nonbenzodiazepine benzodiazepine receptor agonists in pregnant patients are inconclusive. We present a case of insomnia during pregnancy that was managed with doxylamine and zolpidem and discuss the current evidence examining the efficacy and potential adverse effects of treatment with a focus on the nonbenzodiazepine benzodiazepine receptor agonists in the management of insomnia during pregnancy.

CITATION: Tu X, Junna MR, Kolla BP. How do you Zzz during pregnancy? A brief review of Z-drug use and management of insomnia during pregnancy. J Clin Sleep Med. 2025;21(8):1499-1502.