The American journal on addictions · 2006
A randomized, open-label, controlled trial of gabapentin and phenobarbital in the treatment of alcohol withdrawal.
Сравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mariani John J, Rosenthal Richard N, Tross Susan, Singh Prameet, Anand Om P
Аннотация
Gabapentin was compared with phenobarbital for the treatment of alcohol withdrawal in a randomized, open-label, controlled trial in 27 inpatients. There were no significant differences in the proportion of treatment completers between treatment groups or the proportion of patients in each group requiring rescue medication for breakthrough signs and symptoms of alcohol withdrawal. There were no significant treatment differences in withdrawal symptoms or psychological distress, nor were there serious adverse events. These findings suggest that gabapentin may be as effective as phenobarbital in the treatment of alcohol withdrawal. Given gabapentin's favorable pharmacokinetic profile, further study of its effectiveness in treating alcohol withdrawal is warranted.
Предметные рубрики MeSH
AdolescentAdultAlcoholismAminesAnticonvulsantsCyclohexanecarboxylic AcidsDose-Response Relationship, DrugDrug Administration ScheduleEthanolFemaleGabapentinHumansMaleMiddle AgedNeurologic ExaminationPatient AdmissionPersonality InventoryPhenobarbitalSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeTreatment Outcomegamma-Aminobutyric Acid