A simple and rapid protocol for the synthesis of phenacyl derivatives using macroporous polymer-supported reagents.

This article describes the use of Amberlite IRA-910 with different counter ions as excellent polymer-supported reagents in nucleophilic substitution reactions. The versatility of this protocol allowed the synthesis of a diversified library of phenacyl derivatives with high yields. The polymeric reagents can be reloaded several times with no loss of their efficiency.