Veterinary anaesthesia and analgesia · 2025
The effect of cervical epidural injection of morphine and the combination of morphine and detomidine on recovery from anesthesia in adult horses.
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Carroll Anna T, Reed Rachel A, Perlini Michael, Clough Amara E, Rocha Matheus, Moorman Valerie J
Аннотация
OBJECTIVE: To evaluate the effect of cervical epidural injection of morphine alone and morphine in combination with detomidine on recovery from anesthesia in horses.
STUDY DESIGN: Blinded, randomized, crossover, Latin square design.
ANIMALS: A group of six healthy adult horses aged 9 ± 3 years and weighing 471 ± 76 kg (mean ± standard deviation).
METHODS: Horses were administered each of three treatments during a 1 hour general anesthetic with a 4 day washout period. Treatments were: 1) cervical epidural injection of saline 0.011 mL kg-1 (S); 2) morphine 0.1 mg kg-1 (M); and 3) morphine 0.1 mg kg-1 with detomidine 0.01 mg kg-1 (MD). Data evaluating the quality of rope-assisted anesthetic recovery included accelerometry-based recovery score, time to first movement, time to sternal recumbency, time to standing and number of attempts to stand. Data were analyzed using a generalized linear mixed model. Significance was set at p < 0.05.
RESULTS: Recovery scores were 24.4 ± 10.0, 23.9 ± 6.7 and 19.9 ± 7.7 for treatments S, M and MD, respectively (p = 0.463). Times for first movement, sternal recumbency and standing were 33 ± 16, 22 ± 18 and 45 ± 10 minutes; 48 ± 26, 57 ± 29 and 69 ± 25 minutes; and 55 ± 20, 61 ± 28 and 70 ± 23 minutes for treatments S, M and MD, respectively.
CONCLUSIONS: Cervical epidural injection of morphine alone and morphine with detomidine did not negatively affect recovery compared with saline.
CLINICAL RELEVANCE: The use of cervical epidural injection of morphine alone or morphine in combination with detomidine does not negatively affect the recovery quality of horses from general anesthesia.
STUDY DESIGN: Blinded, randomized, crossover, Latin square design.
ANIMALS: A group of six healthy adult horses aged 9 ± 3 years and weighing 471 ± 76 kg (mean ± standard deviation).
METHODS: Horses were administered each of three treatments during a 1 hour general anesthetic with a 4 day washout period. Treatments were: 1) cervical epidural injection of saline 0.011 mL kg-1 (S); 2) morphine 0.1 mg kg-1 (M); and 3) morphine 0.1 mg kg-1 with detomidine 0.01 mg kg-1 (MD). Data evaluating the quality of rope-assisted anesthetic recovery included accelerometry-based recovery score, time to first movement, time to sternal recumbency, time to standing and number of attempts to stand. Data were analyzed using a generalized linear mixed model. Significance was set at p < 0.05.
RESULTS: Recovery scores were 24.4 ± 10.0, 23.9 ± 6.7 and 19.9 ± 7.7 for treatments S, M and MD, respectively (p = 0.463). Times for first movement, sternal recumbency and standing were 33 ± 16, 22 ± 18 and 45 ± 10 minutes; 48 ± 26, 57 ± 29 and 69 ± 25 minutes; and 55 ± 20, 61 ± 28 and 70 ± 23 minutes for treatments S, M and MD, respectively.
CONCLUSIONS: Cervical epidural injection of morphine alone and morphine with detomidine did not negatively affect recovery compared with saline.
CLINICAL RELEVANCE: The use of cervical epidural injection of morphine alone or morphine in combination with detomidine does not negatively affect the recovery quality of horses from general anesthesia.