Australian and New Zealand journal of public health · 2018
Culture-positive shigellosis cases are epidemiologically different to culture-negative/PCR-positive cases.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Quinn Emma, Najjar Zeina, Huhtinen Esther, Jegasothy Edward, Gupta Leena
Аннотация
OBJECTIVE: To review the epidemiological differences between culture-positive and culture-negative (but ipaH PCR-positive) cases of shigellosis in Sydney Local Health District (SLHD), NSW, to inform whether changes to the national case definition for shigellosis are required.
METHODS: An audit of all cases of shigellosis (culture-positive vs. culture-negative/PCR-positive) in SLHD from 1 January 2013 to 30 June 2015 was conducted and demographic, clinical and risk factors were analysed and compared between these groups.
RESULTS: Of the 148 shigellosis cases notified to SLHD, 122 cases (85 culture-positive vs. 37 culture-negative) were included for analysis. Culture-positive cases were more likely than culture-negative/PCR-positive cases to have experienced at least three symptoms (OR 3.18, 95%CI 1.3-7.5), been hospitalised (OR 4.2, 95%CI 1.4-13.2), and have had men-who-have-sex-with-men exposure identified as the source of their infection (OR 28.7, 95%CI 6.2-132.6).
CONCLUSIONS: This study has identified that culture-positive vs. culture-negative/PCR-positive shigellosis cases in NSW differ by clinical severity and risk factors for infection. Implications for public health: The study findings warrant further research to determine the true diagnostic prevalence of Shigella in the culture-negative/PCR-positive group in the Australian context, in order to inform further changes to the national case definition for shigellosis.
METHODS: An audit of all cases of shigellosis (culture-positive vs. culture-negative/PCR-positive) in SLHD from 1 January 2013 to 30 June 2015 was conducted and demographic, clinical and risk factors were analysed and compared between these groups.
RESULTS: Of the 148 shigellosis cases notified to SLHD, 122 cases (85 culture-positive vs. 37 culture-negative) were included for analysis. Culture-positive cases were more likely than culture-negative/PCR-positive cases to have experienced at least three symptoms (OR 3.18, 95%CI 1.3-7.5), been hospitalised (OR 4.2, 95%CI 1.4-13.2), and have had men-who-have-sex-with-men exposure identified as the source of their infection (OR 28.7, 95%CI 6.2-132.6).
CONCLUSIONS: This study has identified that culture-positive vs. culture-negative/PCR-positive shigellosis cases in NSW differ by clinical severity and risk factors for infection. Implications for public health: The study findings warrant further research to determine the true diagnostic prevalence of Shigella in the culture-negative/PCR-positive group in the Australian context, in order to inform further changes to the national case definition for shigellosis.