Recent advances in the pharmacologic and behavioral management of chemotherapy-induced emesis.

Chemotherapy protocols that induce severe protracted nausea and vomiting are stressful for cancer patients, and the fear that may be associated with chemotherapy often outweighs other negative aspects of the cancer experience. The clinical management of chemotherapy-induced emesis involves pharmacologic approaches, maintenance of hydration, provision of emotional support, and the possible use of behavioral relaxation techniques. We review the literature on the psychological side effects of chemotherapy and offer recommendations for the pharmacologic, supportive, and behavioral treatment of chemotherapy-induced emesis. More effective management of chemotherapy-induced nausea and vomiting also enhances patient compliance and therefore potentially decreases overall morbidity and mortality.