A double blind comparative study of mianserin and a fixed combination of amitriptyline plus chlordiazepoxide.

A double-blind comparative trial was carried out in 64 depressed out-patients, comparing mianserin with a fixed combination of amitriptyline + chlordiazepoxide. Both preparations proved to be equally effective at the end of the trial, but the mianserin group showed a considerable therapeutic improvement at the end of the second week, in comparison to the other group. With regard to side-effects, mianserin produced by far less side-effects than the combination of amitriptyline + chlordiazepoxide. It was concluded that mianserin should be considered as one of the most suitable drugs for the treatment of depressed out-patients.