[Giant panniculectomy].

Severe obesity is a growing health challenge, and some experience disabling functional problems despite major weight loss. In this case report, we present two male patients with giant pannus, resulting in limited mobility, recurrent infections, and social restrictions. Both underwent giant panniculectomy, removing 34.6 kg and 18.9 kg of tissue, respectively. Postoperative results included regaining the ability to walk without mobility aids, resuming physical activity, and increasing social interaction. Giant panniculectomy can provide substantial quality-of-life improvement in selected patients.