Ocular immunology and inflammation · 2019
Herpetic Anterior Uveitis in a Chinese Referral Center: Clinical Manifestations and Laboratory Test Results.
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Qian Zhuyun, Fan Hua, Tao Yong, Li Wensheng, Gu Wei
Аннотация
PURPOSE: To describe and to compare the clinical manifestation and laboratory test results of herpetic anterior uveitis (HAU) caused by Herpes simplex virus (HSV) and varicella-zoster virus (VZV).
METHODS: A retrospective, observational study on patients diagnosed with HAU. Etiology, clinical features, ocular complications, and recurrences of the infection were evaluated as main clinical parameters. The aqueous Interleukin-8 (IL-8) level was also measured to assess the intraocular inflammation.
RESULTS: Thirty-two eyes (32 patients) were involved. Among all involved cases, 24 had VZV-AU and 8 had HSV-AU. Common clinical features of HAU included the presence of KPs (90.6%), distorted pupil (83.3%), Iris atrophy (71.9%) and corneal edema (50%). The intraocular fluid analysis showed higher viral load and IL-8 level in VZV-AU.
CONCLUSIONS: Compared with HSV-AU, the intraocular inflammation was more severe in VZV-AU. The intraocular fluid analysis was valuable for the etiological diagnosis and the evaluation of disease severity.
METHODS: A retrospective, observational study on patients diagnosed with HAU. Etiology, clinical features, ocular complications, and recurrences of the infection were evaluated as main clinical parameters. The aqueous Interleukin-8 (IL-8) level was also measured to assess the intraocular inflammation.
RESULTS: Thirty-two eyes (32 patients) were involved. Among all involved cases, 24 had VZV-AU and 8 had HSV-AU. Common clinical features of HAU included the presence of KPs (90.6%), distorted pupil (83.3%), Iris atrophy (71.9%) and corneal edema (50%). The intraocular fluid analysis showed higher viral load and IL-8 level in VZV-AU.
CONCLUSIONS: Compared with HSV-AU, the intraocular inflammation was more severe in VZV-AU. The intraocular fluid analysis was valuable for the etiological diagnosis and the evaluation of disease severity.
Предметные рубрики MeSH
AcyclovirAdolescentAdultAgedAged, 80 and overAntiviral AgentsAqueous HumorAsian PeopleChinaDrug Therapy, CombinationEye Infections, ViralFemaleGlucocorticoidsHerpes Zoster OphthalmicusHerpesviridae InfectionsHerpesvirus 3, HumanHumansInterleukin-8MaleMiddle AgedReferral and ConsultationRetrospective StudiesSimplexvirusUveitis, AnteriorValacyclovirViral LoadVisual AcuityYoung Adult