Fundamental & clinical pharmacology · 2020
Amiodarone and Parkinsonism: a pharmacovigilance study.
СтатьяНазвание и аннотация: Перевод в очереди
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Montastruc Jean-Louis, Durrieu Geneviève
Аннотация
BACKGROUND: Some case reports have described parkinsonism with amiodarone. We investigated a putative association between parkinsonism and exposure to amiodarone.
METHODS: We used the WHO pharmacovigilance database (VigiBase® ). All adverse drug reactions with 'Parkinson-like events' and amiodarone were included. Four disproportionality analyses were performed: 1/after inclusion of all reports, 2/according to sex, 3/for the twenty last years (2000-2019), and 4/after exclusion of concomitant drugs known to induce parkinsonism (antipsychotic, antivertigo, antiemetic antinauseant drugs, flunarizine). Results are expressed as reporting odds ratios (ROR; 95% CI) and information component (IC).
RESULTS: No significant association was found in the whole population [ROR = 0.83 (0.65-1.06), IC = -0.7 (IC025 = -0.65)], in men, in women, for the 2000-2019 years, or after exclusion of drugs inducing parkinsonism.
CONCLUSION: We failed to find any signal of parkinsonism with amiodarone. We suggest that reports of parkinsonism with amiodarone could be mainly explained by other underlying causes.
METHODS: We used the WHO pharmacovigilance database (VigiBase® ). All adverse drug reactions with 'Parkinson-like events' and amiodarone were included. Four disproportionality analyses were performed: 1/after inclusion of all reports, 2/according to sex, 3/for the twenty last years (2000-2019), and 4/after exclusion of concomitant drugs known to induce parkinsonism (antipsychotic, antivertigo, antiemetic antinauseant drugs, flunarizine). Results are expressed as reporting odds ratios (ROR; 95% CI) and information component (IC).
RESULTS: No significant association was found in the whole population [ROR = 0.83 (0.65-1.06), IC = -0.7 (IC025 = -0.65)], in men, in women, for the 2000-2019 years, or after exclusion of drugs inducing parkinsonism.
CONCLUSION: We failed to find any signal of parkinsonism with amiodarone. We suggest that reports of parkinsonism with amiodarone could be mainly explained by other underlying causes.