Metformin Ameliorates Neuronal Necroptosis after Intracerebral Hemorrhage by Activating AMPK.

BACKGROUND

Intracerebral hemorrhage (ICH) is a major cause of death and disability globally. As a type of secondary injury after ICH, treatment for cell death can promote the recovery of neurological function.

METHODS

Among all the cell death, neuronal necroptosis has recently been demonstrated of significance in the pathogenesis of ICH. However, the administration of drugs against necroptosis has many limitations.

RESULTS

In the present study, we found that metformin, a first-line medication for the treatment of type 2 diabetes, can effectively inhibit neuronal necroptosis after ICH by activating the AMPK related pathway, thereby significantly improving neurological function scores and reducing brain edema.

CONCLUSION

These results will provide a new perspective for future research in necroptosis.