The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2014
Neurobiology and temperament in the offspring of excellent lithium responders.
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Ferensztajn Ewa, Skibinska Maria, Kaczmarek Mariusz, Losy Jacek, Rybakowski Janusz K
Аннотация
OBJECTIVES: The aim of the study was to assess neurobiological and temperamental correlates in offspring of lithium-treated patients, related to parental lithium response.
METHODS: The study comprised 27 female and 23 male subjects, aged 17-54 years, the offspring of 36 bipolar patients receiving lithium for 5-38 years. Thirteen subjects were offspring of excellent lithium responders (ELR), 25 of partial lithium responders and 12 of lithium non-responders. In all subjects, serum brain-derived neurotrophic factor (BDNF), matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were measured, and the subjects were assessed by the Temperament Scale of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) and the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) scale.
RESULTS: In offspring of the ELR, the percentage of persons treated for mood disorder was higher (46 vs. 16%), and higher mean BDNF and MMP-9 levels and lower IL-6 levels were found, compared with the remaining subjects. There were also differences between the ELR and the remaining patients on the TEMPS-A and O-LIFE scale, and within the ELR, between subjects treated for mood disorders and the healthy ones.
CONCLUSIONS: The offspring of ELR show distinct neurobiological and temperamental profiles compared to other lithium-treated patients.
METHODS: The study comprised 27 female and 23 male subjects, aged 17-54 years, the offspring of 36 bipolar patients receiving lithium for 5-38 years. Thirteen subjects were offspring of excellent lithium responders (ELR), 25 of partial lithium responders and 12 of lithium non-responders. In all subjects, serum brain-derived neurotrophic factor (BDNF), matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were measured, and the subjects were assessed by the Temperament Scale of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) and the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) scale.
RESULTS: In offspring of the ELR, the percentage of persons treated for mood disorder was higher (46 vs. 16%), and higher mean BDNF and MMP-9 levels and lower IL-6 levels were found, compared with the remaining subjects. There were also differences between the ELR and the remaining patients on the TEMPS-A and O-LIFE scale, and within the ELR, between subjects treated for mood disorders and the healthy ones.
CONCLUSIONS: The offspring of ELR show distinct neurobiological and temperamental profiles compared to other lithium-treated patients.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntipsychotic AgentsBiomarkersBipolar DisorderBrain-Derived Neurotrophic FactorFemaleHumansInterleukin-6Lithium CompoundsMaleMatrix Metalloproteinase 9Middle AgedMood DisordersPsychiatric Status Rating ScalesSurveys and QuestionnairesTemperamentTumor Necrosis Factor-alphaYoung Adult