Human psychopharmacology · 2012
Olanzapine and food craving: a case control study.
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Abbas Mohammed J, Liddle Peter F
Аннотация
BACKGROUND: Antipsychotic-induced weight gain is a problematic side effect. The mechanism is still not fully understood. Carbohydrate (and possibly other food) cravings have been suggested in literature, but not been systematically investigated.
OBJECTIVES: To investigate the hypothesis that food cravings, especially for carbohydrate, are responsible for olanzapine-induced weight gain.
METHOD: A case control design was used to measure general and specific food cravings using Food Craving Inventory (White et al., 2002) in three groups: patients with a diagnosis of schizophrenia taking olanzapine (Number = 20) or typical antipsychotics (Number = 20) and in a healthy control group (Number = 20).
RESULTS: No statistically significant differences were found between the three groups in the craving scores. There was a trend in the typical group to show more cravings than other groups.
CONCLUSION: Our study failed to prove the hypothesis that carbohydrate craving is responsible for olanzapine-induced weight gain. This conclusion is limited by the small number of the subjects included.
OBJECTIVES: To investigate the hypothesis that food cravings, especially for carbohydrate, are responsible for olanzapine-induced weight gain.
METHOD: A case control design was used to measure general and specific food cravings using Food Craving Inventory (White et al., 2002) in three groups: patients with a diagnosis of schizophrenia taking olanzapine (Number = 20) or typical antipsychotics (Number = 20) and in a healthy control group (Number = 20).
RESULTS: No statistically significant differences were found between the three groups in the craving scores. There was a trend in the typical group to show more cravings than other groups.
CONCLUSION: Our study failed to prove the hypothesis that carbohydrate craving is responsible for olanzapine-induced weight gain. This conclusion is limited by the small number of the subjects included.